Development, Applications and Challenges of Nanomedicine
Keywords:
nanopartículas, nanomedicina, nanodrogas, aplicaciones biomédicas.Abstract
Introduction: Biotechnology facilitates the construction of tools that seek to improve the weaknesses presented by allopathic drugs.
Objective: To describe aspects related to nanomedicine with mechanisms to improve the care and quality of life of people.
Development: Conceptual aspects of nanotechnology, nanomedicine, nanotherapy, nanoparticles, nanomaterials, nanocarriers and classification by practical areas (diagnosis, therapy, regenerative medicine), dimensions (zero, uni, bi, tri), mechanisms of action (administration, stability, slow and controlled release, among others), nanosystems, origin (natural, secondary or manufactured; metallic/inorganic, non-metallic/organic, organometallic) are considered. Challenges facing nanomedicine and its various branches are enunciated.
Conclusions: In nanomedicine, several applications are designed, researched and implemented in order to better address situations that affect the quality of life of people even though there are still theoretical-conceptual, methodological (standardized procedures) and practical-clinical (efficacy, safety, quality, efficiency) challenges that must be overcome.
Keywords: nanoparticles; nanomedicine; nanodrugs, biomedical applications.Downloads
Download data is not yet available.
References
1.Gómez M. Usos terapéuticos de nanomateriales y nanopartículas. Revista Repertorio de Medicina y Cirugía. 2019; 28(1): 5-11. https://revistas.fucsalud.edu.co/index.php/repertorio/article/view/871/900
2.Dhiman N, Awasthi R, Sharmal B, Kharkwal H, Kulkarni G. Lipid nanoparticles as carriers for bioactive delivery. Frontiers in Chemistry. 2021; 9: 580118. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107723/
3.Fernandes F, Diaz M, Delerue C, Grosso C. Critical Review of Lipid-Based Nanoparticles as Carriers of Neuroprotective Drugs and Extracts. Nanomaterials. 2021; 11(563): 1-43. https://www.mdpi.com/2079-4991/11/3/563
4.Uskoković V. Health economics matters in the nanomaterial world: Cost-effectiveness of utilizing an inhalable antibacterial nanomaterial for the treatment of multidrug-resistant pneumonia. Technology in Society. 2021 Aug 1;66:101641. https://www.sciencedirect.com/science/article/pii/S0160791X21001160
5.Delshadi R, Bahrami A, McClements D, Moore M, Williams L. Development of nanoparticle-delivery systems for antiviral agents: A review. Journal of Controlled Release. 2021;331:30-44. https://www.sciencedirect.com/science/article/pii/S0168365921000262
6.Abbasi A, Haghjooy S, Asadnia M, Razmjou A. Recent advances in nanomaterials development for nanomedicine and cancer. ACS Applied Bio Materials. 2021; 4(8): 5908-5925. https://pubs.acs.org/doi/abs/10.1021/acsabm.1c00591
7.Afzal M, Alharbi K, Alruwaili N, Al-Abassi F, Al-Malki A, Kazmi I, Anwar F. Nanomedicine in treatment of breast cancer–A challenge to conventional therapy. In Seminars in cancer biology. 2021; 69: 279-292. Academic Press. https://www.sciencedirect.com/science/article/pii/S1044579X19304158
8.Ertas Y, Dorcheh K, Akbari A, Jabbari E. Nanoparticles for Targeted Drug Delivery to Cancer Stem Cells: A Review of Recent Advances. Nanomaterials. 2021; 11(1755):1-25. https://www.mdpi.com/2079-4991/11/7/1755
9.Rama G, Dariya B, Kumar S, Chalikonda G, Kang S, Khan I, Sushma P, Nagaraju G, Pavitra E, Han Y. Nanomaterials multifunctional behavior for enlightened cancer therapeutics. Seminars in cancer biology. 2021; 69:168-189. https://www.sciencedirect.com/science/article/pii/S1044579X19301907
10.Rahman M, Mohammad A. Cancer Nanotherapeutics: Targeted medicine, therapeutic vaccination and Challenges with cancer nanomedicines. Seminars in cancer biology. 2021; 69: 1-4. https://pubmed.ncbi.nlm.nih.gov/33571666/
11.Lim S, Cox A, Tung M, Chung E. Clinical progress of nanomedicine-based RNA therapies. Bioactive Materials. 2021. https://www.sciencedirect.com/science/article/pii/S2452199X21004825
12.Karaosmanoglu S, Zhou M, Shi B, Zhang X, Williams G, Chen X. Carrier-free nanodrugs for safe and effective cancer treatment. Journal of Controlled Release. 2021;329:805-832. https://www.sciencedirect.com/science/article/pii/S016836592030585X
13.Hu D, Zhang W, Tang J, Zhou Z, Liu X, Shen Y. Improving safety of cancer immunotherapy via delivery technology. Biomaterials. 2021; 265 (120407):1-17. https://www.sciencedirect.com/science/article/pii/S0142961220306530
14.Grewal I, Singh S, Arora S, Sharma N. Polymeric nanoparticles for breast cancer therapy: A comprehensive review. Biointerface Res. Appl. Chem. 2021; 11: 11151-11171. https://biointerfaceresearch.com/wp-content/uploads/2020/12/20695837114.1115111171.pdf
15.Khan H, Mirzaei H, Amiri A, Akkol E, Halimi S, Mirzaei H.. Glyco-nanoparticles: New drug delivery systems in cancer therapy. Seminars in cancer biology. 2021;69:24-42. https://www.sciencedirect.com/science/article/pii/S1044579X19304006
16.Pawar K, Kachave R, Kanawade M, Zagre V. A Review on Nanoparticles Drug Delivery System. Journal of Drug Delivery and Therapeutics. 2021; 11(4): 101-104. http://www.jddtonline.info/index.php/jddt/article/view/4865
17.Wan Z, Sun R, Moharil P, Chen J, Liu Y, Song X, Ao Q. Research advances in nanomedicine, immunotherapy, and combination therapy for leukemia. Journal of Leukocyte Biology. 2021; 109(2): 425-436. https://jlb.onlinelibrary.wiley.com/doi/abs/10.1002/JLB.5MR0620-063RR
18.Martínez R, Becerra J, Marco M, Vicent M, Arenas J, Carracedo Á, Lapunzina P, Martín F. Informes anticipando nanomedicina. España: Fundación Instituto Roche, Observatorio de tendencias en la medicina del futuro, Ascendo Sanidad&Farma, 2021. (aprox. 28 p). www.institutoroche.es
19.Mitchell M, Billingsley M, Haley R, Wechsler M, Peppas N, Langer R. Engineering precision nanoparticles for drug delivery. Nature Reviews Drug Discovery. 2021; 20(2): 101-124. https://www.nature.com/articles/s41573-020-0090-8
20.Bulbake U, Doppalapudi S, Kommineni N, Khan W. Liposomal formulations in clinical use: an updated review. Pharmaceutics. 2017;9(2): 12. https://www.mdpi.com/1999-4923/9/2/12
21.Rojas Y, Aguado K, González I. La nanomedicina y los sistemas de liberación de fármacos: ¿la (r)evolución de la terapia contra el cáncer?. Educación química. 2016; 27(4): 286-291.https://doi.org/10.106/j.eq.2016.07.02
22.Rennick J, Johnston A, Parton R. principles and methods for studying the endocytosis of biological and nanoparticle therapeutics. Nature Nanotechnology. 2021;16(3): 266-276. https://www.nature.com/articles/s41565-021-00858-8
23.Hoang T, Suys E, Lee J, Nguyen D, Park K, Truong N. Lipid-Based Nanoparticles in the Clinic and Clinical Trials: From Cancer Nanomedicine to COVID-19 Vaccines. Vaccines. 2021; 9(359):1-28. https://www.mdpi.com/2076-393X/9/4/359
24.Suñé M, Limeres M, Moreno C, Hernández C, Suñé J, Cuestas M, Suñé C. Innovative therapeutic and delivery approaches using nanotechnology to correct splicing defects underlying disease. Frontiers in Genetics. 2020; 11(731): 1-22. https://www.frontiersin.org/articles/10.3389/fgene.2020.00731/full
25.Boix P, Soriano P, de Benito A, Orzáez M, Vicent M. The Past, Present, and Future of Breast Cancer Models for Nanomedicine Development. Advanced Drug Delivery Reviews. 2021; 173: 306-330. https://www.sciencedirect.com/science/article/pii/S0169409X2100096X
26.Anselmo A, Mitragotri S. Nanoparticles in the clinic: An update post COVID‐19 vaccines. Bioengineering & translational medicine. 2021; 6(3): e10246. https://aiche.onlinelibrary.wiley.com/doi/full/10.1002/btm2.10246
27.Márquez E, Hernández D, Míguez M, Soler F, Pérez M. Las nanopartículas y sus aplicaciones. España: Universidad de Extremadura, 2021. (aprox 76 p). https://dehesa.unex.es/handle/10662/11784
28.Milewska S, Niemirowicz-Laskowska K, Siemiaszko G, Nowicki P, Wilczewska AZ, Car H. Current Trends and Challenges in Pharmacoeconomic Aspects of Nanocarriers as Drug Delivery Systems for Cancer Treatment. International journal of nanomedicine. 2021;16:6593. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487283/
29.Yodsanit N, Wang B, Zhao Y, Guo L, Kent G, Gong S. Recent progress on nanoparticles for targeted aneurysm treatment and imaging. Biomaterials. 2021; 265(120406):1-15. https://www.sciencedirect.com/science/article/pii/S014296122030652946.
30.Massaro S, Lorenzoni G. Nanomedicine: a socio-technical system. Technological Forecasting and Social Change. 2021; 173 (121066): 1-11. https://www.sciencedirect.com/science/article/pii/S0040162521004984
31.Cote B, Rao D, Alani A. Nanomedicine for Drug Delivery throughout the Alimentary Canal. Molecular Pharmaceutics. 2021. https://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.0c00694
32.Hayat H, Nukala A, Nyamira A, Fan J, Wang P. A concise review: the synergy between artificial intelligence and biomedical nanomaterials that empowers nanomedicine. Biomedical Materials. 2021; 16(052001):1-8. https://iopscience.iop.org/article/10.1088/1748-605X/ac15b2/meta
33.Ren C, Wang Z, Zhang X, Gao J, Gao Y, Zhang Y, Liu J, Yang C, Liu J. Construction of all-in-one peptide nanomedicine with photoacoustic imaging guided mild hyperthermia for enhanced cancer chemotherapy. Chemical Engineering Journal. 2021; 405 (127008):1-10. https://www.sciencedirect.com/science/article/pii/S1385894720331363
34.Kim E, Lim E, Park G, Park C, Lim J, Lee H, Haam S. Advanced Nanomaterials for Preparedness Against (Re‐) Emerging Viral Diseases. Advanced Materials. 2021; 2005927: 1-32. https://onlinelibrary.wiley.com/doi/full/10.1002/adma.202005927
35.Maslanka S, Fleischmann D, Goepferich A. Biomedical nanoparticle design: What we can learn from viruses. Journal of Controlled Release. 2021; 329: 552-569. https://pubmed.ncbi.nlm.nih.gov/33007365/
36.Sargazi, Saman, Mukhtar M, Radhar A, Barani M, Pandey S, Díez A. Active Targeted Nanoparticles for Delivery of Poly (ADP-ribose) Polymerase (PARP) Inhibitors: A Preliminary Review. International Journal of Molecular Sciences. 2021; 22 (10319): 1-19. https://www.mdpi.com/1422-0067/22/19/10319
37.Wu P, Zhang B, Wiredu D, Xu W, Qian H.Extracellular vesicles: A bright star of nanomedicine Extracellular vesicles: A bright star of nanomedicine. Biomaterials. 2021; 269(120467):1-24 https://doi.org/10.1016/j.biomaterials.2020.120467
38.Chowdhury N, Deepika, Chowdhury R, Sonawane G, Mavinamar S, Lyu X, Pandey R, Chang C. Nanoparticles as an Effective Drug Delivery System in Covid-19. Biomedicine & Pharmacotherapy. 2021; 143: 112162. https://www.sciencedirect.com/science/article/pii/S075333222100946X
39.Basha S, Dhandayuthabani R, Syed M, Sugantha V. Solid lipid nanoparticles for oral drug delivery. Materials Today: Proceedings. 2021; (36): 313-324.
https://www.sciencedirect.com/science/article/pii/S2214785320327243
40.Sarraf M, Nasiri B, Yeong C, Hosseini H, Saber S, Basirun W, Tsuzuki T. Mixed oxide nanotubes in nanomedicine: A dead-end or a bridge to the future?. Ceramics International. 2021; 47(3): 2917-2948. https://www.sciencedirect.com/science/article/pii/S0272884220328820
41.Yang Y, Santamaria P. Evolution of nanomedicines for the treatment of autoimmune disease: from vehicles for drug delivery to inducers of bystander immunoregulation. Advanced Drug Delivery Reviews. 2021;176(113898):1-12. https://www.sciencedirect.com/science/article/pii/S0169409X2100291X
42.Sofias A, Combes F, Koschmieder S, Storm G, Lammers T. A paradigm shift in cancer nanomedicine: From traditional tumor targeting to leveraging the immune system. Drug discovery today. 2021; 26(6):1482-1489. https://www.sciencedirect.com/science/article/pii/S1359644621001008
43.Caldonazo A, Almeida S, Bonetti A, Lazo R, Mengarda M, Murakami F. Pharmaceutical applications of starch nanoparticles: A scoping review. International Journal of Biological Macromolecules. 2021; 181:697-704. https://www.sciencedirect.com/science/article/pii/S014181302100578X
44.Amiri M, Mohammadzadeh V, Yazdi M, Barani M, Rahdar A, Kyzas G. Plant-Based Gums and Mucilages Applications in Pharmacology and Nanomedicine: A Review. Molecules. 2021; 26(1770):1-23. https://www.mdpi.com/1420-3049/26/6/1770
45.Qambrani A, Rehman F, Tanziela T, Shaikh S, Semcheddine F, Du T, Wang X. Biocompatible exosomes nanodrug cargo for cancer cell bioimaging and drug delivery. Biomedical Materials. 2021; 16(025026):1-14.
https://iopscience.iop.org/article/10.1088/1748-605X/abaaa2/meta
46.Gao X, Li L, Cai X Huan Q, Xiao T, Cheng Y. Targeting nanoparticles for diagnosis and therapy of bone tumors: Opportunities and challenges. Biomaterials, 2021; 265 (120404): 1-21. https://www.sciencedirect.com/science/article/pii/S0142961220306505
47.Sanità G, Carrese B, Lamberti A. Nanoparticle surface functionalization: how to improve biocompatibility and cellular internalization. Frontiers in molecular biosciences. 2020; 7(587012): 1-20. https://www.frontiersin.org/articles/10.3389/fmolb.2020.587012/full
48.Varahachalam S, Lahooti B, Chamaneh M, Bagchi S, Chhibber T, Morris K, Kaushik A. Nanomedicine for the SARS-CoV-2: state-of-the-art and future prospects. International journal of nanomedicine. 2021; 16, 539. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837559/
49.Gul AR, Shaheen F, Rafique R, Bal J, Waseem S, Park TJ. Grass-mediated biogenic synthesis of silver nanoparticles and their drug delivery evaluation: A biocompatible anti-cancer therapy. Chemical Engineering Journal. 2021 Mar 1;407:127202.https://www.sciencedirect.com/science/article/pii/S1385894720333295
50.Zhang X, Duan X, Hu Y, Tang Z, Miao C, Tao W, Wu J. One-step and facile synthesis of peptide-like poly (melphalan) nanodrug for cancer therapy. Nano Today. 2021; 37(101098):1-12. https://www.sciencedirect.com/science/article/pii/S1748013221000232?via%3Dihub
51.Mahajan R. Onasemnogene abeparvovec for spinal muscular atrophy: The costlier drug ever. Int J App Basic Med Res 2019; 9:127-8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652281/pdf/IJABMR-9-127.pdf
52.Lu L, Sun Y, Wan C, Hu Y, Lo P, Lovell J, Jin H. Role of intravital imaging in nanomedicine-assisted anti-cancer therapy. Current Opinion in Biotechnology. 2021; 69: 153-161. https://pubmed.ncbi.nlm.nih.gov/33476937/
53.Gupta N, Bahl S, Bagha A, Vaid S, Javaid M, Haleem, A. Nanomedicine technology and COVID-19 outbreak: Applications and challenges. Journal of Industrial Integration and Management. 2021. https://www.worldscientific.com/doi/abs/10.1142/S2424862221500123
2.Dhiman N, Awasthi R, Sharmal B, Kharkwal H, Kulkarni G. Lipid nanoparticles as carriers for bioactive delivery. Frontiers in Chemistry. 2021; 9: 580118. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107723/
3.Fernandes F, Diaz M, Delerue C, Grosso C. Critical Review of Lipid-Based Nanoparticles as Carriers of Neuroprotective Drugs and Extracts. Nanomaterials. 2021; 11(563): 1-43. https://www.mdpi.com/2079-4991/11/3/563
4.Uskoković V. Health economics matters in the nanomaterial world: Cost-effectiveness of utilizing an inhalable antibacterial nanomaterial for the treatment of multidrug-resistant pneumonia. Technology in Society. 2021 Aug 1;66:101641. https://www.sciencedirect.com/science/article/pii/S0160791X21001160
5.Delshadi R, Bahrami A, McClements D, Moore M, Williams L. Development of nanoparticle-delivery systems for antiviral agents: A review. Journal of Controlled Release. 2021;331:30-44. https://www.sciencedirect.com/science/article/pii/S0168365921000262
6.Abbasi A, Haghjooy S, Asadnia M, Razmjou A. Recent advances in nanomaterials development for nanomedicine and cancer. ACS Applied Bio Materials. 2021; 4(8): 5908-5925. https://pubs.acs.org/doi/abs/10.1021/acsabm.1c00591
7.Afzal M, Alharbi K, Alruwaili N, Al-Abassi F, Al-Malki A, Kazmi I, Anwar F. Nanomedicine in treatment of breast cancer–A challenge to conventional therapy. In Seminars in cancer biology. 2021; 69: 279-292. Academic Press. https://www.sciencedirect.com/science/article/pii/S1044579X19304158
8.Ertas Y, Dorcheh K, Akbari A, Jabbari E. Nanoparticles for Targeted Drug Delivery to Cancer Stem Cells: A Review of Recent Advances. Nanomaterials. 2021; 11(1755):1-25. https://www.mdpi.com/2079-4991/11/7/1755
9.Rama G, Dariya B, Kumar S, Chalikonda G, Kang S, Khan I, Sushma P, Nagaraju G, Pavitra E, Han Y. Nanomaterials multifunctional behavior for enlightened cancer therapeutics. Seminars in cancer biology. 2021; 69:168-189. https://www.sciencedirect.com/science/article/pii/S1044579X19301907
10.Rahman M, Mohammad A. Cancer Nanotherapeutics: Targeted medicine, therapeutic vaccination and Challenges with cancer nanomedicines. Seminars in cancer biology. 2021; 69: 1-4. https://pubmed.ncbi.nlm.nih.gov/33571666/
11.Lim S, Cox A, Tung M, Chung E. Clinical progress of nanomedicine-based RNA therapies. Bioactive Materials. 2021. https://www.sciencedirect.com/science/article/pii/S2452199X21004825
12.Karaosmanoglu S, Zhou M, Shi B, Zhang X, Williams G, Chen X. Carrier-free nanodrugs for safe and effective cancer treatment. Journal of Controlled Release. 2021;329:805-832. https://www.sciencedirect.com/science/article/pii/S016836592030585X
13.Hu D, Zhang W, Tang J, Zhou Z, Liu X, Shen Y. Improving safety of cancer immunotherapy via delivery technology. Biomaterials. 2021; 265 (120407):1-17. https://www.sciencedirect.com/science/article/pii/S0142961220306530
14.Grewal I, Singh S, Arora S, Sharma N. Polymeric nanoparticles for breast cancer therapy: A comprehensive review. Biointerface Res. Appl. Chem. 2021; 11: 11151-11171. https://biointerfaceresearch.com/wp-content/uploads/2020/12/20695837114.1115111171.pdf
15.Khan H, Mirzaei H, Amiri A, Akkol E, Halimi S, Mirzaei H.. Glyco-nanoparticles: New drug delivery systems in cancer therapy. Seminars in cancer biology. 2021;69:24-42. https://www.sciencedirect.com/science/article/pii/S1044579X19304006
16.Pawar K, Kachave R, Kanawade M, Zagre V. A Review on Nanoparticles Drug Delivery System. Journal of Drug Delivery and Therapeutics. 2021; 11(4): 101-104. http://www.jddtonline.info/index.php/jddt/article/view/4865
17.Wan Z, Sun R, Moharil P, Chen J, Liu Y, Song X, Ao Q. Research advances in nanomedicine, immunotherapy, and combination therapy for leukemia. Journal of Leukocyte Biology. 2021; 109(2): 425-436. https://jlb.onlinelibrary.wiley.com/doi/abs/10.1002/JLB.5MR0620-063RR
18.Martínez R, Becerra J, Marco M, Vicent M, Arenas J, Carracedo Á, Lapunzina P, Martín F. Informes anticipando nanomedicina. España: Fundación Instituto Roche, Observatorio de tendencias en la medicina del futuro, Ascendo Sanidad&Farma, 2021. (aprox. 28 p). www.institutoroche.es
19.Mitchell M, Billingsley M, Haley R, Wechsler M, Peppas N, Langer R. Engineering precision nanoparticles for drug delivery. Nature Reviews Drug Discovery. 2021; 20(2): 101-124. https://www.nature.com/articles/s41573-020-0090-8
20.Bulbake U, Doppalapudi S, Kommineni N, Khan W. Liposomal formulations in clinical use: an updated review. Pharmaceutics. 2017;9(2): 12. https://www.mdpi.com/1999-4923/9/2/12
21.Rojas Y, Aguado K, González I. La nanomedicina y los sistemas de liberación de fármacos: ¿la (r)evolución de la terapia contra el cáncer?. Educación química. 2016; 27(4): 286-291.https://doi.org/10.106/j.eq.2016.07.02
22.Rennick J, Johnston A, Parton R. principles and methods for studying the endocytosis of biological and nanoparticle therapeutics. Nature Nanotechnology. 2021;16(3): 266-276. https://www.nature.com/articles/s41565-021-00858-8
23.Hoang T, Suys E, Lee J, Nguyen D, Park K, Truong N. Lipid-Based Nanoparticles in the Clinic and Clinical Trials: From Cancer Nanomedicine to COVID-19 Vaccines. Vaccines. 2021; 9(359):1-28. https://www.mdpi.com/2076-393X/9/4/359
24.Suñé M, Limeres M, Moreno C, Hernández C, Suñé J, Cuestas M, Suñé C. Innovative therapeutic and delivery approaches using nanotechnology to correct splicing defects underlying disease. Frontiers in Genetics. 2020; 11(731): 1-22. https://www.frontiersin.org/articles/10.3389/fgene.2020.00731/full
25.Boix P, Soriano P, de Benito A, Orzáez M, Vicent M. The Past, Present, and Future of Breast Cancer Models for Nanomedicine Development. Advanced Drug Delivery Reviews. 2021; 173: 306-330. https://www.sciencedirect.com/science/article/pii/S0169409X2100096X
26.Anselmo A, Mitragotri S. Nanoparticles in the clinic: An update post COVID‐19 vaccines. Bioengineering & translational medicine. 2021; 6(3): e10246. https://aiche.onlinelibrary.wiley.com/doi/full/10.1002/btm2.10246
27.Márquez E, Hernández D, Míguez M, Soler F, Pérez M. Las nanopartículas y sus aplicaciones. España: Universidad de Extremadura, 2021. (aprox 76 p). https://dehesa.unex.es/handle/10662/11784
28.Milewska S, Niemirowicz-Laskowska K, Siemiaszko G, Nowicki P, Wilczewska AZ, Car H. Current Trends and Challenges in Pharmacoeconomic Aspects of Nanocarriers as Drug Delivery Systems for Cancer Treatment. International journal of nanomedicine. 2021;16:6593. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487283/
29.Yodsanit N, Wang B, Zhao Y, Guo L, Kent G, Gong S. Recent progress on nanoparticles for targeted aneurysm treatment and imaging. Biomaterials. 2021; 265(120406):1-15. https://www.sciencedirect.com/science/article/pii/S014296122030652946.
30.Massaro S, Lorenzoni G. Nanomedicine: a socio-technical system. Technological Forecasting and Social Change. 2021; 173 (121066): 1-11. https://www.sciencedirect.com/science/article/pii/S0040162521004984
31.Cote B, Rao D, Alani A. Nanomedicine for Drug Delivery throughout the Alimentary Canal. Molecular Pharmaceutics. 2021. https://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.0c00694
32.Hayat H, Nukala A, Nyamira A, Fan J, Wang P. A concise review: the synergy between artificial intelligence and biomedical nanomaterials that empowers nanomedicine. Biomedical Materials. 2021; 16(052001):1-8. https://iopscience.iop.org/article/10.1088/1748-605X/ac15b2/meta
33.Ren C, Wang Z, Zhang X, Gao J, Gao Y, Zhang Y, Liu J, Yang C, Liu J. Construction of all-in-one peptide nanomedicine with photoacoustic imaging guided mild hyperthermia for enhanced cancer chemotherapy. Chemical Engineering Journal. 2021; 405 (127008):1-10. https://www.sciencedirect.com/science/article/pii/S1385894720331363
34.Kim E, Lim E, Park G, Park C, Lim J, Lee H, Haam S. Advanced Nanomaterials for Preparedness Against (Re‐) Emerging Viral Diseases. Advanced Materials. 2021; 2005927: 1-32. https://onlinelibrary.wiley.com/doi/full/10.1002/adma.202005927
35.Maslanka S, Fleischmann D, Goepferich A. Biomedical nanoparticle design: What we can learn from viruses. Journal of Controlled Release. 2021; 329: 552-569. https://pubmed.ncbi.nlm.nih.gov/33007365/
36.Sargazi, Saman, Mukhtar M, Radhar A, Barani M, Pandey S, Díez A. Active Targeted Nanoparticles for Delivery of Poly (ADP-ribose) Polymerase (PARP) Inhibitors: A Preliminary Review. International Journal of Molecular Sciences. 2021; 22 (10319): 1-19. https://www.mdpi.com/1422-0067/22/19/10319
37.Wu P, Zhang B, Wiredu D, Xu W, Qian H.Extracellular vesicles: A bright star of nanomedicine Extracellular vesicles: A bright star of nanomedicine. Biomaterials. 2021; 269(120467):1-24 https://doi.org/10.1016/j.biomaterials.2020.120467
38.Chowdhury N, Deepika, Chowdhury R, Sonawane G, Mavinamar S, Lyu X, Pandey R, Chang C. Nanoparticles as an Effective Drug Delivery System in Covid-19. Biomedicine & Pharmacotherapy. 2021; 143: 112162. https://www.sciencedirect.com/science/article/pii/S075333222100946X
39.Basha S, Dhandayuthabani R, Syed M, Sugantha V. Solid lipid nanoparticles for oral drug delivery. Materials Today: Proceedings. 2021; (36): 313-324.
https://www.sciencedirect.com/science/article/pii/S2214785320327243
40.Sarraf M, Nasiri B, Yeong C, Hosseini H, Saber S, Basirun W, Tsuzuki T. Mixed oxide nanotubes in nanomedicine: A dead-end or a bridge to the future?. Ceramics International. 2021; 47(3): 2917-2948. https://www.sciencedirect.com/science/article/pii/S0272884220328820
41.Yang Y, Santamaria P. Evolution of nanomedicines for the treatment of autoimmune disease: from vehicles for drug delivery to inducers of bystander immunoregulation. Advanced Drug Delivery Reviews. 2021;176(113898):1-12. https://www.sciencedirect.com/science/article/pii/S0169409X2100291X
42.Sofias A, Combes F, Koschmieder S, Storm G, Lammers T. A paradigm shift in cancer nanomedicine: From traditional tumor targeting to leveraging the immune system. Drug discovery today. 2021; 26(6):1482-1489. https://www.sciencedirect.com/science/article/pii/S1359644621001008
43.Caldonazo A, Almeida S, Bonetti A, Lazo R, Mengarda M, Murakami F. Pharmaceutical applications of starch nanoparticles: A scoping review. International Journal of Biological Macromolecules. 2021; 181:697-704. https://www.sciencedirect.com/science/article/pii/S014181302100578X
44.Amiri M, Mohammadzadeh V, Yazdi M, Barani M, Rahdar A, Kyzas G. Plant-Based Gums and Mucilages Applications in Pharmacology and Nanomedicine: A Review. Molecules. 2021; 26(1770):1-23. https://www.mdpi.com/1420-3049/26/6/1770
45.Qambrani A, Rehman F, Tanziela T, Shaikh S, Semcheddine F, Du T, Wang X. Biocompatible exosomes nanodrug cargo for cancer cell bioimaging and drug delivery. Biomedical Materials. 2021; 16(025026):1-14.
https://iopscience.iop.org/article/10.1088/1748-605X/abaaa2/meta
46.Gao X, Li L, Cai X Huan Q, Xiao T, Cheng Y. Targeting nanoparticles for diagnosis and therapy of bone tumors: Opportunities and challenges. Biomaterials, 2021; 265 (120404): 1-21. https://www.sciencedirect.com/science/article/pii/S0142961220306505
47.Sanità G, Carrese B, Lamberti A. Nanoparticle surface functionalization: how to improve biocompatibility and cellular internalization. Frontiers in molecular biosciences. 2020; 7(587012): 1-20. https://www.frontiersin.org/articles/10.3389/fmolb.2020.587012/full
48.Varahachalam S, Lahooti B, Chamaneh M, Bagchi S, Chhibber T, Morris K, Kaushik A. Nanomedicine for the SARS-CoV-2: state-of-the-art and future prospects. International journal of nanomedicine. 2021; 16, 539. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837559/
49.Gul AR, Shaheen F, Rafique R, Bal J, Waseem S, Park TJ. Grass-mediated biogenic synthesis of silver nanoparticles and their drug delivery evaluation: A biocompatible anti-cancer therapy. Chemical Engineering Journal. 2021 Mar 1;407:127202.https://www.sciencedirect.com/science/article/pii/S1385894720333295
50.Zhang X, Duan X, Hu Y, Tang Z, Miao C, Tao W, Wu J. One-step and facile synthesis of peptide-like poly (melphalan) nanodrug for cancer therapy. Nano Today. 2021; 37(101098):1-12. https://www.sciencedirect.com/science/article/pii/S1748013221000232?via%3Dihub
51.Mahajan R. Onasemnogene abeparvovec for spinal muscular atrophy: The costlier drug ever. Int J App Basic Med Res 2019; 9:127-8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652281/pdf/IJABMR-9-127.pdf
52.Lu L, Sun Y, Wan C, Hu Y, Lo P, Lovell J, Jin H. Role of intravital imaging in nanomedicine-assisted anti-cancer therapy. Current Opinion in Biotechnology. 2021; 69: 153-161. https://pubmed.ncbi.nlm.nih.gov/33476937/
53.Gupta N, Bahl S, Bagha A, Vaid S, Javaid M, Haleem, A. Nanomedicine technology and COVID-19 outbreak: Applications and challenges. Journal of Industrial Integration and Management. 2021. https://www.worldscientific.com/doi/abs/10.1142/S2424862221500123
Downloads
Published
2022-03-10
How to Cite
1.
Jiménez Herrera LG. Development, Applications and Challenges of Nanomedicine. INFODIR [Internet]. 2022 Mar. 10 [cited 2025 Oct. 3];(38). Available from: https://revinfodir.sld.cu/index.php/infodir/article/view/1216
Issue
Section
Review or Position Articles
License
Those authors who have published with this journal, accept the following terms:
a. The authors will keep their copyright and guarantee the magazine the right of first publication of their work, which will be simultaneously subject to the Creative Commons Attribution License that allows third parties to share the work as long as the author and first publication of this magazine are indicated.
b. The authors may adopt other non-exclusive license agreements for the distribution of the published version of the work (e.g., deposit it in an institutional telematic archive or publish it in a monographic volume) as long as the initial publication in this journal is indicated.
c. Authors are allowed and recommended to disseminate their work through the Internet (e.g.: in institutional telematic archives or in their web page) before and during the submission process, which may produce interesting exchanges and increase the number of citations of the published work. (See The effect of open access).
